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Pharmacodynamic effects of nicotine on the cardiovascular system: Nicotines effects on the cardiovascular system include increased heart rate, cardiac output, and blood pressure as well as cutaneous and coronary vasoconstriction (Benowitz, 1992)

10 Varenicline, a nicotine acetylcholine receptor partial agonist, reduces cravings

The idea again is to ascribe the effect to an additive that is already naturally occurring in tobacco, and then to possibly manipulate that additive: a) dental caries [tooth decay], b) reduction in constipation, c) heart rate regulation, d) effects in colds (i.e., mentholated brands), [and] e) anxiety reduction.103 No information is available on the extent to which Philip Morris engaged in subsequent action to study or incorporate the beneficial additives discussed at these meetings

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